![]() Cognitive performance was assessed once every roughly 2 years over 4 Waves, from baseline to approximately 7–10 years later for a given participant.ĭata on aged subjects (92.7% Caucasian, non-Hispanic) was obtained from the ADNI database (). There were 912 non- APOE4 (129 APOE ε2/ε2 or ε2/ε3 783 APOE ε3/ε3) participants with TOMM40 ‘523 and neuropsychological data. Participants were originally recruited from 40–65 years of age. Late middle-aged subjects (91.3% Caucasian, non-Hispanic) were recruited from the WRAP study. APOE4 subjects were not considered for this report, as their in-phase TOMM40 genotype (“Long”, or L) is different and could confound effects of S and VL genotypes in APOE ε3/ε4 subjects. AST, also called glutamic oxaloacetate transaminase, differs in CSF levels among AD patients and related dementias, and shows higher concentrations in AD frontal and parietal cortices. Cytosol AST is an enzyme that facilitates catabolism of glucogenic amino acids through the malate-aspartate shuttle by a final conversion step of aspartate to oxaloacetate, helping to maximize ATP production through glycolysis. To establish that FH and TOMM40 meaningfully interacted to affect mitochondrial processes, CSF levels of a cytosolic aspartate aminotransferase (AST) peptide were gauged. ![]() Previous WRAP and ADNI reports either focused on cross-sectional cognition with fewer subjects or age of onset but not cognitive or mitochondrial outcomes. The primary outcomes were longitudinal memory decline in both cohorts and global decline in the aged cohort. Our objective was to explore FH and TOMM40 interactions separately in non- APOE4 late middle-aged or aged subjects from the Wisconsin Registry for Alzheimer’s Prevention (WRAP) study or Alzheimer’s Disease Neuroimaging Initiative (ADNI) respectively, to see if FH or FHM modulated TOMM40 effects in middle-age and along the AD spectrum in old age. As neurons in hippocampus and other medial temporal lobe (MTL) areas have high ATP requirements, FH and TOMM40 might interact to affect mitochondrial dysfunction and contribute to memory and global cognitive decline, as well as cognitive impairment risk. To link FH and TOMM40 with AD, the mitochondrial cascade hypothesis posits that multiple factors determine baseline and age-related decline in mitochondrial function. ![]() Like TOMM40, FH can increase AD risk independent of APOE. For example, maternal FH (FHM) is related to reduced cytochrome oxidase activity, leading to electron transport chain dysfunction, lower ATP production, and neuronal damage. Both FH and TOMM40 influence mitochondrial bioenergetic processes needed for adenosine triphosphate (ATP) synthesis. AD FH is typically defined as maternal or paternal LOAD onset between ages 65 to 80. It may be important to account for other factors that can modulate mitochondrial function, such as AD family history (FH). However, other reports with large samples have found no effect or a benefit of TOMM40 VL on age of onset and memory decline. To date, several studies have also found that TOMM40 VL in non- APOE4’s or APOE ε3/ε4’s predicts memory deficits or earlier age of AD onset. ![]() Some studies find that subjects with the VL allele have worse memory and executive function scores in middle-aged and aged cohorts. Among non- APOE4’s, the phase-in haplotypes are APOE ε3-linked to either a TOMM40 ‘523 “short” (S) or “very long” (VL) poly-T length. In addition, a TOMM40 variable length deoxythymidine-homopolymer (poly-T) at rs10524523 (‘523) within intron 6 has sometimes been shown to associate with LOAD risk. Genome-wide association studies (GWAS) have implicated several TOMM40 single nucleotide polymorphisms (SNPs) in increased LOAD risk, cognitive decline, and brain atrophy, particularly SNP rs2075650 that has consistently shown such associations. TOMM40 constitutes the central channel of the outer mitochondrial membrane, through which mitochondria-specific ribosomal pre-proteins enter for post-translational modification in the inner matrix. TOMM40 shares strong linkage disequilibrium (LD) with APOE on chromosome 19. As mitochondrial dysfunction is associated with LOAD, several groups have investigated gene loci that impact mitochondrial bioenergetics, such as Translocase of Outer Mitochondrial Membrane-40kD ( TOMM40). ![]() Subjects without the ε4 allele (non- APOE4s) are considered at neutral risk but show substantial variability for developing AD, where there is tremendous interest in finding genetic risk factors for non- APOE4’s that strongly predict memory, global decline, and cognitive impairment risk. The Apolipoprotein E ( APOE) gene is the most replicated genetic risk factor for late-onset Alzheimer’s disease (LOAD). ![]()
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![]() ![]() Instructions.pdf - Original instruction manual.LICENSE.md - Licensing information (see also below).CHANGELOG.md - Bugdom-vita and Bugdom version history.BUILD.md - How to build Bugdom VPK on Linux.A third level of detail has been added between high and low.Settings have been added to allow reversing camera and flight controls.Controller navigation has been added to all menus and most cheat codes.There are only 3 save slots, but you can back up the files from this directory to effectively have more. This is simply a port of excellent work, so new features are beyond the scope of this project (unless they are straightforward and Vita-specific). If you notice any bugs (.), please feel free to open an issue. The levels are a bit slow to load, typically taking ~15s. Overall the port seems to run quite smoothly. Here's the official strategy guide for the game: Pangea Software's official Bugdom cheat page has maps of the levels: In gameįor all in-game cheats, you must simultaneously hold down the left and right shoulder buttons ( L1+R1) along with a given key. ![]() Hold down L1 and R1 and select the START icon to bring up a level select dialog. The following have been implemented: In main menu Controls and cheatsĬontrols are the same as they were implemented by the help (nut) item in the main menu explains them.Ĭheats have been given new controls. Once you have libshaccg.suprx, you can then download and install the Bugdom VPK from the release page. Therefore, you must first install libshaccg.suprx for instructions see. The Vita port uses Rinnegatamante's VitaGL library. For more information on the history of Bugdom and rewrite, see. This is a port of Pangea Software's Bugdom to PlayStation Vita, based on the modern version of Bugdom written by Iliyas Jorio. ![]() ![]() The Episcopal Church describes itself as " Protestant, yet Catholic" and claims apostolic succession, tracing its bishops back to the apostles via holy orders. The church was organized after the American Revolution, when it became separate from the Church of England, whose clergy are required to swear allegiance to the British monarch as Supreme Governor of the Church of England. The church has recorded a regular decline in membership and Sunday attendance since the 1960s, particularly in the Northeast and Upper Midwest. In 2015, Pew Research estimated that 1.2 percent of the adult population in the United States, or 3 million people, self-identify as mainline Episcopalians. In 2011, it was the nation's 14th largest denomination. The presiding bishop of the Episcopal Church is Michael Bruce Curry, the first African American bishop to serve in that position.Īs of 2021, the Episcopal Church had 1,678,157 members, of whom 1,520,388 were in the United States. ![]() It is a mainline Protestant denomination and is divided into nine provinces. The Episcopal Church, based in the United States with additional dioceses elsewhere, is a member church of the worldwide Anglican Communion. La Iglesia Episcopal Protestante de los Estados Unidos de América, L’Église épiscopale, L’Église protestante épiscopale des États-Unis d’Amérique The Protestant Episcopal Church in the United States of America, La Iglesia Episcopal, Personal Ordinariate of the Chair of Saint Peter in the Catholic Church (2012)ġ,520,388 active baptized members in the U.S.Anglican Church in North America (2009).Episcopal Church in the Philippines (1990). ![]() Anglican Episcopal Church of Brazil (1965). ![]() Northern and Southern Provinces of the Moravian Church in Americaġ979 Book of Common Prayer, Revised Common Lectionary Unitary ( General Convention of the Episcopal Church in the United States of America) Mainline Protestant (with various theological and doctrinal identities, including Anglo-Catholic, Liberal and Evangelical) Arms of the Episcopal Church: Argent a cross throughout gules, on a canton azure nine cross crosslets in saltire of the field. ![]() ![]() ![]() ![]() ![]() With his knowledge of many different styles of martial arts that include Shōtōkan, Wadō-ryū, Taekwondo, Judo, Brazilian Jiu-Jitsu, Muay Thai, Wing Chun, Jeet Kune Do, and Aikido, Frank collected the most practical applications, modified them with his own philosophies and created his own blend of American Karate, "Toso Kune Do" ( 斗争拳道, lit. Karate ( Shōtōkan, Wado-ryu), Judo, Wing Chun, Jeet Kune Do, Taekwondo, Muay Thai, Aikido, Brazilian Jiu-Jitsu It is currently in post-production and was set to release in March 2023 in view of Frank's death (see below) in 2022, the film is now scheduled to released on his 50th Birthday, September 4th 2023, Labor Day.įighting and martial arts Toso Kune Do Focus Other cast members include Mark Dacascos, Michael Madsen, Andrew Byron Bachelor, and Jenna Frank. The film includes past Power Rangers performers such as Frank, Jason Faunt, and Ciara Hanna. With the popularity and excitement, it grew into a full-feature film. Initially it was going to be a mini-series or fan film. The film Legend of the White Dragon launched on Kickstarter in 2020. Valiant paid tribute to Frank on their Twitter after his death. Frank was considered as superior to Vin Diesel's incarnation of the character in 2020. The series was released in 2018 to positive reception from fans. ![]() the Valiant Universe which is based on the Valiant Universe as Bloodshot. In 2016, Frank was cast in the web series Ninjak vs. After success with the Super Power Beatdown series, Bat in the Sun began developing a web reality series of Frank titled My Morphing Life. He appeared again on May 5, 2015, as the Green Ranger and fought Ryu from Street Fighter. On November 7, 2013, Frank appeared on Super Power Beatdown as the White Ranger taking on Scorpion from Mortal Kombat. In August 2022, Frank revealed that he had retired from the franchise. In 2018, he reprised his role as Tommy in episode 10 of Power Rangers Super Ninja Steel for the 25th anniversary of Power Rangers. įrank had a cameo role in the 2017 film Power Rangers, as a citizen of Angel Grove, alongside fellow Power Rangers actress Amy Jo Johnson. Frank expressed interest in developing a Green Ranger solo series or feature film after an encounter with Stan Lee at a comic book convention. įrank reprised his role as Tommy Oliver (who in turn was the Green Ranger for the episode) in the season finale of Power Rangers Super Megaforce. He joked that Saban and Disney are "both the same, they're cheap" but that he was impressed with the production crew for Dino Thunder. Being the Black Dino Ranger was a favor to Douglas Sloan. This was also the case during "Forever Red" of Wild Force. During this time, Frank was always shown in long-sleeved shirts to cover the tattoos on his arms. He then reprised his role in 2004 in Power Rangers Dino Thunder, as the Black Dino Ranger. During mid-season, Frank and fellow cast members Johnny Yong Bosch, Nakia Burrise and Catherine Sutherland agreed to leave and were replaced.Īfter he left the series in 1997, Frank came back to Power Rangers as the Red Zeo Ranger in 2002 for the special 10th-anniversary episode, entitled " Forever Red", in Power Rangers Wild Force, which brought back ten former Red Rangers, and reunited him with Austin St. The following year in Power Rangers Turbo, his character became the first Red Turbo Ranger. Frank's character became the Red Zeo Ranger (also called Zeo Ranger V). The transition is part of the annual Ranger suit change to match the annual change of the Super Sentai series. The character Adam Steele was renamed Ryan Steele.Īfter three seasons, Mighty Morphin Power Rangers transitioned into Power Rangers Zeo. However, due to Tommy Oliver's popularity with Power Rangers fans, Frank was brought back, with Tommy Oliver becoming the White Ranger. According to both Frank and Brad Hawkins, Hawkins' character was to replace Tommy Oliver originally as the White Ranger on Power Rangers. įrank was supposed to be the lead character Adam Steele in VR Troopers (originally called Cybertron) and shot a pilot episode before being called back to Power Rangers. The role was set for 14 episodes, but due to the popularity of the character he was brought back as the White Ranger and the new leader of the team. It was confirmed by his niece that he died due to suicide.įrank was cast in the role of Tommy Oliver, the Green Ranger in Mighty Morphin Power Rangers. He appeared in Power Rangers Zeo as Tommy Oliver's brother David Trueheart. įrank had an older brother named Erik Frank. He was best known for his role as Tommy Oliver in the Power Rangers television franchise.įrank was born in Covina, California on September 4, 1973. Jason David Frank (Septem– November 19, 2022) was an American actor and martial artist. ![]() ![]() ![]() Which we proceed to smash into one another. Trying something oddball with the scenario, just to shake things up, as well as a lot of rarely seen units. ![]() We play an asymmetric 3-way stage coach heistīattle Report, Scourge vs PHR vs Shaltari, 1500pt Data Extraction There's only two options for '10mm urban city' game mats for Dropzone I can find, so lets do a side by side review of themīattle Report, Resistance vs PHR vs Shaltari, 1250pt, 'Precious Cargo' We play an asymmetric 3-way assault on a defended positionĭropzone Commander Mat Review - Deep Cut Studios VS Table War Much procrastination but eventually, the write up though mostly pictures of a Demolition centric 3p scenario involving the Aegis Defense Laser model.īattle Report, Scourge vs PHR vs Shaltari, 1250pt, 'Defend the Bunker' Pimping the game with improvements to the default components and chitsĭropfleet Commander - UCMF Shipyards Commission New Heavy Ships įinished the Battlecruisers and Battleship for Dropfleet UCM, and the San Fran bays I kinda forgot in my last batchĭropfleet Battle Reports, UCM vs PHR, Beach Weekend īeach Weekend Battles! Over a mini-vacation weekend at a friend's beach house, we found time for more games of Dropfleet.īattle Report, Resistance vs PHR vs Shaltari, 1500pt, 'Orbital Laser' ![]() Holotank Upgrades for UCMF Commanders (Dial Replacements & Better Tokens) Let's see what TTCombat can produce with 3 years. ![]() 3 years of time to playtest, refine, tweak, balance, improve, and optimize designs. 3 years of hints and glimpses and rumors and 'leaks'. It's been 3 years since the first teasers of Battle for Earth came out. But, it's not unheard of outside of the Drop games.īehemoths Released, We Playtest Them First ~10mm SF Miniature Lines Scale Comparison: Completed ġ0mm SF is the middle child of the non-28s, neither as prevalent as 6 or 15. I stumbled upon another similar scale combined arms game, then just had some fun painting it up. Impressions from the first learning games of Heavy Gear Blitz 3.1 Edition There's not nearly enough close up angle shots on these models around the web, so here we go. Heavy Gear Southern Special Forces Reinforcements įinished assembling painting and basing some Special Forces and Elites for my Heavy Gear Southern army. I've scrapped like 3 partially written articles and I'm just going to do a big summary of it all and move forward. I've gotten behind as blogs are want to do, and it's only partially excused by a breakneck work schedule me and missus have been laboring under combined with my own procrastination. Much fun was had, many pics and notes within. 7 different games in 2 and a third days, ranging from spaceships to Napoleonics to zombie survival to ACW brown water naval action. My second year at MillenniumCon, a mostly-historical mostly-miniatures mostly-wargames convention in my metro area. Year's end and I'm making some surprising last minute progress on a number of fronts. Squeezed in a 150tv game of Heavy Gear Blitz in the waining hours of 2022, though we accidentally played it with older v2 scenarios. Heavy Gear Upate: New South Units, Battle Reports įinished painting some new Southern Heavy Gear units, played a few games of the same since last I posted a summary.īattle Report: Southern Republican Army vs NuCoalition I finally finished my Black Talon force for Heavy Gear Blitz. This is the largest book we've ever released, with a staggering 304 pages filled to the brim with Dropzone and Dropfleet.Heavy Gear: Black Talon Taskforce Finished The book also includes rules for using Behemoths in your games - colossal war engines that can turn the tide of an entire battle! Some rules have been tweaked, but there are many brand new surprises. This set of rules has been developed over several years, and is the one that the fans have been waiting for. Written by David J Lewis and Lewis Clarke, this book contains a huge amount of material! With a massive new chapter in the story, be prepared to learn about brand new parts of the universe, including the biggest battles ever fought.ĭropfleet Commander fans will find rules for all sorts of new ships, including the massive Dreadnoughts and much-anticipated Monitors, as well as full rules for Resistance fleets - the newest players in this intergalactic game.ĭropzone Commander players will find a full new version of the rules. It takes the ongoing narrative and puts it into overdrive as the Reconquest faces its bloodiest conflicts yet, both in space and on the ground. Battle for Earth is the first cross-game expansion for Dropfleet Commander and Dropzone Commander. ![]() ![]() ![]() There are 10 eligible impairment types in Para Athletics: eight physical impairments as well as vision impairment and intellectual impairment. To be eligible to compete in Para athletics, a person must have an eligible impairment and meet the minimum impairment criteria set out in the World Para Athletics Classification Rules and Regulations. The details of classification in Para athletics are set out in the World Para Athletics Classification Rules and Regulations (link provided below). More information about classification can be found here. This, to a certain extent, is similar to grouping athletes by age, gender or weight.Ĭlassification across the Paralympic Movement is governed by the IPC Athlete Classification Code and Standards. The groupings of athletes by the degree of activity limitation resulting from their impairments are called 'Sport Classes'. Having an impairment is thus not sufficient for an athlete to compete in Para sport. This is done to safeguard the integrity of fair competition.Ĭlassification is sport-specific because an impairment affects the ability to perform in different sports to a different extent. As a consequence, an athlete may meet the criteria in one sport, but may not meet the criteria in another sport. For further questions please contact WHAT IS CLASSIFICATION?Ĭlassification determines which athletes are eligible to compete in a sport and how those athletes are then grouped together for competition in order to minimise the impact of the athletes' impairments on sport performance. In all cases the sport-specific classification rules will take precedence. This is a brief overview of classification in the sport and is in no way legally binding. ![]() ![]() ![]() ![]() The Rhino and Kaenon Arlo is also a good solid design and can take the abuse. The Kaenon Hard Kore is a one of a kind pair of eyewear. These have one of the best lenses with a ground-breaking polarized SR-91 lens. You can mix and match lenses if you like and they also have a vented lens which really sets them apart from the other companies out there. The Tifosi brand are known for being super light weight and are really big in the biking community. These are one of the lightest and best fitting glasses you will find and the price point is very bearable at about $60 or so. I know many Team guys who swear by these and have continued to use them even after leaving the Navy. The Oakley Crankshaft has all the right angles and full coverage for working out on the boats or coming into town for a beer at McP’s or Danny’s. This has been a go-to pair of eyewear for Team Guys for many years. If they fit your face and budget are they are super cool. Question: How do you like Gatorz vs Oakley?Īnswer: The Gatorz are unique in that they are metal and have a unique style. They also take a fair amount of abuse without breaking. We have seen numerous frogs sporting this pair of shades out on the streets. These are lightweight and will not slide on your head while your running. The Oakley Half Jacket 2.0gets the job done out in the ocean or in the desert so it works like a charm for Team guys out at work or play. This has been one of Oakley’s top selling glasses and is definitely the eye catcher with tons of style. When you buy through our links we may receive a commission that helps keep our business open and supporting other Veterans. Our website is Veteran-owned and is reader-supported. #1 Pro-Tip: Find the pair that fits your face and matches the light conditions you will working most in. Rankings based on in-field reports and off the grid check ins at local bars. You got to have a good pair of glasses when you are working out on the SWCC boats in the ocean or doing field work in the desert. Whether you are protecting your eyes from dust and grime or just looking cool for the ladies – its all good. Check out this list of the favorite tactical sunglasses used by Navy SEALs out in training and on the streets. ![]() ![]() ![]() They also offer frequent coupons and promo codes to help you save. Besides prints and enlargements there is a big array of photo gifts and products you can make and there are options for in-store pickup or home delivery on most items. They do a lot more than merely print your photos. With locations everywhere it certainly is convenient. resources/images/category/books/row7-tile1-810圆70-092515.I have never been a big fan of drugstore printing and photo products because I thought they were inferior to online digital photo printing services such as Shutterfly, but I was pleasantly surprised that Walgreens Photo Center does quite a good job. resources/images/foil_swatches/wg-custom-foil.png Stationer圜ardstockPremium,stationer圜ardstockFoil Special trims not available for Same Day Pickup. Special trims only available with premium cardstock. 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Foil Cards add a touch of glamour to your greetings. ![]() CommerceProduct_68791, CommerceProduct_69042, CommerceProduct_68794, CommerceProduct_69052, CommerceProduct_71593, CommerceProduct_66962, CommerceProduct_69049,CommerceProduct_85674 ![]() ![]() ![]() In the past decade, Cavaliers have had a 735 per cent increase in AKC registrations, more than any other breed.To this day, there are two separate national Cavalier clubs, one AKC affiliated and one not. The AKC recognized the Cavalier in 1996 amidst great controversy.Fanciers disagreed, however, over whether they wanted AKC recognition. Cavaliers came to America in the 1940s. Cavaliers King Charles Spaniels are paw-sitively charming little dogs and are the largest breed within the toy category. Cavaliers are kind, gentle and loyal dogs which is why they are so popular, but will need constant company as they get very upset at being left alone. ![]() But only when a Cavalier won Best in Show at the prestigious Crufts dog show did the breed capture the public's attention.
![]() HOST, verb transitive To give entertainment to. HOST, verb intransitive To lodge at an inn to take up entertainment. He was born in Bristol in April 1769, the son of a tavern-keeper, and grew up at his fathers celebrated coaching inn, the Black Bear, on the Devizes road in Wiltshire. In the Romish church, the sacrifice of the mass, or the consecrated wafer, representing the body of Christ, or as the Catholics allege, transubstantiated into his own body. In fear of a beating from his hard-drinking debtor father, a tavern-keeper, he ran away from home at 13 and returned when he was almost 16. An army a number of men embodied for war. A tavern keeper in Van Horn, the birdman of Port OConnor: fifteen Texans who give their community its character. 'In the Yule-Log Glow, Book I' by Various. ![]() HOST, noun The sense is probably transferred from a single foe to an army of foes.]ġ. (n) tavern keeper the keeper of a public house Usage in the news Abner Eddy, one of the countys early tavern-keepers, came to the area from New England by a most circuitous route. All the servants had dressed up, some as bears, Turks, tavern-keepers, or fine ladies others as mongrel monsters. The innkeeper says of the traveler, he has a good host and the traveler says of his landlord, he has a kind host A guest one who is entertained at the house of another. but a means also, and paradoxically, through which they could define social distance and cultural space. ![]() One who entertains another at his house for reward an innkeeper a landlord.ģ. Homer never entertained guests or hosts with long speeches.Ģ. One who entertains another at his own house, without reward. ![]() |